Stasiuk A. Phosphorus-containing polyesters of L-glutamic acid for biomedical application

The dissertation is devoted to developing a method for obtaining phosphoruscontaining polyesters based on derivatives of dibasic natural α-amino acids and polyethylene glycols; an ethyl phosphate or phosphate group was previously introduced in the structure of diols. The phosphorus-containing polyesters were obtained by the method of irreversible activated polycondensation according to the Steglich esterification reaction. They were also establishing their structure and studying colloidal-chemical properties as promising materials for creating dispersed polymer systems for the transport of medicinal products, particularly antibacterial agents. The presence of phosphate groups in the polyester macrochain makes them suitable for ionic binding of organic substances exhibiting basic properties. The colloidal-chemical properties of phosphorus-containing polyesters are regulated by the molecular weight of polyethylene glycol, which makes it possible to build stable dispersed systems on their basis. The first section discusses the requirements for the carrier material of drug delivery systems, their classification, and application areas. The advantages and disadvantages of each type of nanocarrier are analysed. Polymeric nanoparticles based on polyesters allow the introduction of a therapeutic substance, which is embedded or conjugated with a polymer, to a specific delivery site. Due to the biodegradability and biocompatibility of polyesters and the ability to protect the active component of the drug from degradation and control its release, they are the most promising materials for drug delivery systems for medical purposes. In addition, based on polyesters, it is possible to create systems that would respond to a change in the hydrogen index of the environment and would be subjected to controlled decomposition, thereby providing a controlled release of a pharmaceutical compound.